i-ImmunDx™ Platform and POCT Products

Seinda’s i-ImmunDx™ platform is built on extensive analysis of ophthalmic clinical samples, yielding rich disease biomarker data. Known for its high sensitivity and accuracy, it uses minimal sample volume and provides fast results. The system features a micro-capillary fluid collector, point-of-care diagnostics, and an advanced analyzer, targeting key biomarkers such as LTα3 (LTA), IgE, MMP-9, IL-6, and IL-8.

i-ImmunDx™ enhances clinical diagnostics, supports disease management, and advances scientific research into ocular conditions, contributing significantly to precision medicine.

i-ImmunDx™ Analyzer

The i-ImmunDx™ Analyzer is a highly sensitive reader, specifically designed for Seinda’s POCT strips. It features a fast, user-friendly interface, enabling operators to efficiently test patient samples and access stored results. Compact, lightweight, and portable, it’s ideal for various POCT settings including outpatient clinics, clinical laboratories, and inspection facilities. The analyzer offers two testing modes, providing flexibility to adapt to different workflow demands. It also supports automated results for qualitative, semi-quantitative, and quantitative in vitro immunoassays, enhancing testing efficiency and accuracy.

The i-ImmunDx Analyzer facilitates POC testing to enable precision medicine for improved clinical outcomes through:

– Monitoring of disease status and treat efficacy
– Discrimination of disease etiology
– Selection of targeted treatment

Exclusively intended for use in conjunction with Seinda’s Micro-capillary fluid collectors and POC test kits.

Two Test Modes:

Standard Test: Test cassette is immediately inserted into Analyzer after sample is added, so the user can multi-task during sample reaction time (10-15 minutes)

Quick Test: Test cassette is inserted after the reaction time is complete, allowing multiple tests to be performed in a single time frame(results in seconds).

– High-capacity storage

– Saves results automatically, allowing stored data to be easily aexported onto computers or recovered in the event of power failure.

– Built-in thermal printer for printing test results in real time

– Barcode scanner for easy identification of test cassettes and results

  • Dimensions: 173 mm(W)x84mm(H)x210mm(D)
  • Weight: 1.5kg
To purchase or request more information, send us an email at sales@seindabio.com or send us a message.

i-ImmunDx™ Analyzer

Our lines of Point-of-care testing(POCT)products facilitate in vitro diagnosis of ocular disorders by measuring the quantity of specific biomarkers in tear samples. The test kits are simple to perform and require only 1.0 – 2.2μL of tear fluid.

Quantitative measurements with good precision

Rapid (<15min) results at point-of-care

High sensitivity and specificity

In vitro testing provides mechanistic information at the molecular level. POC tests enable precision medicine for improved clinical outcomes through:

  •  Discrimination of disease etiology
  • Selection of targeted treatment
  • Monitoring of disease status and treat efficacy

Exclusively intended for use in conjunction with Seinda’s fluid collectors and analyzer. 

 

Quantitative detection of lymphotoxin-alpha (LTα3, also abbreviated as LTA) in human tear samples assists in the clinical diagnosis of dry eye.

Research indicates that LTA concentrations in the tears of most dry eye patients are significantly lower than in individuals without dry eye, and these concentrations strongly correlate with the severity of various dry eye symptoms and signs. It is hypothesized that LTA expression on the ocular surface is linked to the proliferation of regulatory T cells and maintaining ocular surface homeostasis. Therefore, detecting LTA concentrations in tears can aid in the diagnosis of dry eye and in assessing its severity.

 

Immunoglobulin E (IgE) POCT quantitatively detects IgE in human tear samples and can assist in the clinical diagnosis of allergic conjunctivitis.

IgE plays a pivotal role in Type I hypersensitivity reactions. Exposure of the conjunctiva to environmental allergens stimulates IgE production, leading to hypersensitivity reactions. This allergen-IgE interaction on sensitized mast cells and basophils triggers cell degranulation, releasing inflammatory mediators and causing Type I allergic conjunctivitis.

Typically, tear IgE levels are low in the absence of disease, but in allergic conjunctivitis patients, they rise significantly. Therefore, measuring IgE concentrations in tears provides a rapid and accurate means to diagnose Type I allergic conjunctivitis.

 

The Matrix Metallopeptidase-9 (MMP-9) POCT quantitatively measures MMP-9 levels in human tear samples, aiding in monitoring ocular surface inflammation and diagnosing dry eye disease.

MMP-9 serves as a crucial biomarker for ocular surface inflammation. While normal individuals typically have low MMP-9 concentrations in their tears, these levels are significantly higher in patients with dry eye. Therefore, measuring tear MMP-9 concentrations is instrumental in assessing ocular surface inflammation, thereby facilitating the diagnosis and classification of dry eye disease.

To purchase or request more information, send us an email at sales@seindabio.com or send us a message.

Micro-Capillary Fluid Collector

The Disposable Micro-Capillary Fluid Collector (DMFC) is an innovative design for easy and precise collection of small fluid quantities.

The DMFC is suitable for the non-invasive collection of tear fluid from the human ocular surface and lower eyelid tear lake.  It can also be used to collect body fluids as sweat, saliva and extracorporeal urine, as well as other non-human fluids.

Can be used in conjunction with Seinda’s test kits and analyzer, or separately as a fluid collection device.

Material: plastic
Available in various sizes, with sterile and nonsterible options.

To purchase or request more information, send us an email at sales@seindabio.com or send us a message.

Brad McMillan

Investment Partner

Brad McMillan, CFA®, CAIA, MAI, is the chief investment officer and a managing principal at Commonwealth. With the firm since 2006, he oversees the firm’s investment and asset management groups and acts as spokesperson for the firm’s investment divisions. Brad comments frequently on the markets and economy for a range of media outlets and writes daily for his blog, the Independent Market Observer. He’s a designated member of the Appraisal Institute, the CFA Institute, and the CAIA Association.

Kim Tillinghast

CPFA™, Principal, Partner

Kim Tillinghast began her career in the banking industry in 1985. She graduated with a degree in Finance from West Texas State University in 1990 and has continued her education by earning her Series 24 General Securities Principal Exam and Certified Plan Fiduciary Advisor (CPFA™). Shortly thereafter she started her brokerage career at a traditional wirehouse in downtown Los Angeles, California in 1991. After relocating to Orange County, Kim became an independent financial advisor in May of 1993. She brings over 37 years in the banking and finance industry with experience ranging from designing, developing, employing and maintaining complex investment strategies, Pension Plans, Employee Stock Option Plans, Corporate Finance, Estate Planning and Transition. Outside of her career, she served as Co-Chair of the Dallas County Susan G. Komen Race for the Cure 2013 and 2014 and currently serves on the Board of the Tillinghast Society, Inc. With a deep love for animals, she continues to volunteer for multiple emergency animal response teams including Red Rover, HSUS, UAN, ASPCA and volunteers weekly at the Irving Animal Shelter. Kim also loves worldwide adventure travel and has many amazing experiences visiting almost half of the world’s countries and all seven continents, twice.

Karthik Muraliraj

CFP®, ChFC®, CLU®, RMA®, Partner

Karthik Muraliraj was raised in Fort Worth, Texas, and developed an interest in investing and economics at a young age. After graduating from the University of Texas at Austin with a Bachelor of Arts in Economics and a minor in Business, he started his career as a financial professional in 2008. Throughout his career, Karthik has continued to educate himself by gaining multiple designations. Since moving to Dallas, he has been an active member in the community—volunteering with organizations such as the network of Indian Professionals, Dallas Autumn Ball and Reading Partners. Karthik is an avid sports fan and enjoys supporting his alma mater as a proud member of the Texas Exes Dallas Chapter. In his free time, Karthik enjoys cooking, travel, fitness and spending time with this wife, son, dog, and cat.

Crystal Arredondo

MBA, CDFA®, CPFA™, Partner

Crystal Arredondo was born and raised in Germany. She moved to Texas following her parents’ decision to retire after serving an overseas career in the Armed Forces. Seeing firsthand the difficult transition to civilian life after retirement, Crystal obtained her MBA in Finance at the University of North Texas and began her career as a financial advisor. In 2009, she completed the Retirement Planning Specialist Program at the Wharton School of Business, University of Pennsylvania. In 2018, she earned her designation of Certified Divorce Financial Analyst® (CDFA®). In 2022, she earned the additional designation as a Certified Plan Fiduciary Advisor (CPFA™). As the daughter of an immigrant mother, she especially enjoys helping women and business owners make decisions that affect their financial independence. She served as the 2015-16 Chair for the National Association of Women Business Owners (NAWBO) and 2016-17 Chair for the NAWBO Institute of Entrepreneurial Development.

Philip Strunk

CFP®, CPA, Partner

Philip Strunk is a native of Houston, TX. Philip earned his Bachelor of Business Administration and Masters in Professional Accounting from the University of Texas at Austin’s McCombs School of Business. He earned his designation as Certified Public Accountant (CPA) in 2004 and CERTIFIED FINANCIAL PLANNER (TM) certification in 2010. Having started his career with Deloitte & Touche, LLP in 2005, Philip spent a year and a half in Deloitte’s Audit and Assurance Services group and provided a variety of financial services for a number of Fortune 500 companies. He decided in late 2006 that his talent and passion for investments were best suited for working with smaller groups and individuals. After obtaining the required securities registrations and insurance licenses, Philip became a financial advisor. The impact was plainly visible and more fulfilling. Philip serves as the Investment Director for MPACT.

John C. Farris

CAP®, CFS®, Partner

John C. Farris is a founding partner and has more than forty years in both public and private business serving in a variety of management and leadership capacities. John completed the Retirement Planning Specialist Program at the Wharton School of Business at the University of Pennsylvania earning the Retirement Planning Specialist designation. John and his family have a history of philanthropic giving through numerous non-profit organizations. John recently completed his designation as a Chartered Advisor in Philanthropy® (CAP®). He is also a member of The International Association of Advisors in Philanthropy. His primary goal is to help people give intelligently with love and thereby experience the true joy of helping others. John lives in Park Cities and has served on the Public Works Advisory Council, as finance director of the BSA West Park District, the BSA Troop 82 Executive Board, and as a BSA Assistant Scoutmaster for Troop 82, Dallas, Texas.